LOCALIZED BONE GROWTH METHOD

Real protruding growth

--v4d6--

and yes, ik what ur thinking, "theres no such thing as local bone growth without pharma", however this is just incorrect.

(or maybe ur not thinking that idfk)

I actually included parts of this method in a previous post which I took down so some of it may seem familiar

Part 1... Introduction and Info

How does it work?

The core mechanism is LMHFV

Low-Magnitude-High-Frequency Vibrations

LMHFV is well studied for bone density increases, however it can also be used for actual protruding longitudinal growth as shown in multiple studies.

There are already some LMHFV protocols however none of them are as good as what will be discussed here.

Information, Studies, Discussion

>>> DONT DNR <<<

LMHFV is generally categorized as 40-60hz optimally and an amplitude of below <.3g

Previously, LMHFV was more of a theoretical mechanism since there weren't really any studies found on craniofacial longitudinal growth, however I was able to find one that completely changed that.

During this modified and improved protocol I will mainly be referencing this study

https://pubmed.ncbi.nlm.nih.gov/36153283/

In this study, they used LMHFV on the back bottom molars(back teeth) at 60hz .3g amplitude for 5 min total daily

The teeth acted as a way for the vibrations to travel into the mandible body and to the condyle.

The purple aka dynamic loading is the LMHFV(60hz, .3g)

Dynamic Load aka LMHFV had a 51% increase in length and a 77% increase on width on the condyle.

There are TONS of studies on LMHFV and I cant be fucked to go through all of them so I took my list and fed it into AI to get a quick lil summary yall can go through. The study above was the main one I wanted to go into since it's the most relevant.

Other Relevant Studies(summarized by AI)

1. Influence of Low-Magnitude High-Frequency Vibration on Bone Cells and Bone Regeneration — PRISMA-guideline systematic review confirming LMHFV enhanced MSC and osteoblast proliferation, accelerated osteogenic differentiation while inhibiting osteoclastogenic differentiation, with Wnt/β-catenin signaling confirmed as the key mechanosensitive pathway and diminished RANKL expression demonstrated. → Frontiers in Bioengineering and Biotechnology 2020
2. LMHFV meta-analysis on dental implants — 15 animal studies, 972 implants, with random effects meta-analysis detecting statistically significant improvement in bone-implant contact (P < 0.0001) and bone volume/total volume (P = 0.001), providing quantitative confirmation of LMHFV driving real measurable bone formation. → PMC Meta-Analysis 2021
3. Effect of LMHFV on osteocytes in the regulation of osteoclasts — LMHF vibration at less than 1g across 20–90 Hz positively influences skeletal homeostasis, with the RANKL/OPG balance shifted by LMHFV through osteocyte mechanosensing, simultaneously driving formation up and resorption down. → PMC 2011
4. Stimulation of Piezo1 by mechanical signals promotes bone anabolism — eLife 2019, establishing Piezo1 as the primary osteocyte mechanosensor. Conditional deletion of Piezo1 reduced bone mass and strength in mice, while a Piezo1 agonist alone increased bone mass mimicking the effects of mechanical loading. → eLife 2019
5. Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in osteocytes — FSS at 9 dyne/cm² for 30 minutes upregulated Piezo1, promoted OPG and inhibited RANKL simultaneously through NOTCH3, showing the same fluid shear signal LMHFV generates drives formation and anti-resorption through a single channel. → PMC 2022
6. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin — Robling et al. Journal of Biological Chemistry 2008, the definitive paper establishing that sclerostin is mechanically regulated. Sost transcripts and sclerostin protein were dramatically reduced by ulnar loading, directly opening the Wnt/β-catenin bone formation pathway. → Journal of Biological Chemistry 2008
7. FRMV at 42.2 Hz significantly promoted osteoblast proliferation and increased alkaline phosphatase activity and ALP gene expression. FRMV at 92.1 Hz showed no effect on proliferation rate. → https://pubmed.ncbi.nlm.nih.gov/40283143/

Part 2... How do you apply it?

Shopping List

1. Bob and Brad Q2 Mini Massage Gun — ~$55 Use the foam/ball head that comes included.

2. SAVILER 660nm & 850nm Red Light Device — ~$15 Highest brightness setting(Optional)

3. Microfiber cloth — ~$4

Total: ~$64

THE BASE OF THE PROTOCOL

The base of the protocol includes the following

Part 1 - RED LIGHT PRIMING — ~5 minutes - OPTIONAL

Device: SAVILER red light 

How: Hold ~8-12 inches from your face. Both wavelengths on (660nm + 850nm combined mode). Maximum brightness. Put the special sunglasses on so you don’t go blind. Hold it around 8-12 inches away it covers your entire face simultaneously. Prop it or hold it

Why: “Charges up” your osteoblasts with ATP and upregulates Runx2 before mechanical stimulus hits. Basically it pre-loads the cells to respond maximally to the signals coming next.

Studies(summarized by AI)

1. Red (635nm) and NIR (808nm) photobiomodulation on human osteoblasts and mesenchymal stromal cells — red light at 635nm activated Akt signaling in human osteoblasts, while NIR at 808nm modified Runx2 expression and mineralization pattern, directly validating the wavelengths the SAVILER emits acting on human osteoblasts. → NCBI PMC — Human Osteoblast Study
2. Red (660nm) and near-infrared (810nm) photobiomodulation stimulates proliferation in human adipose-derived stem cells — Scientific Reports 2017, Nature Publishing Group. Red and NIR wavelengths had positive effects on both proliferation and osteogenic differentiation including measurable RUNX2, osterix, and osteocalcin expression. → Scientific Reports 2017
3. Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1 — International Journal of Oral Science, Nature 2022. NIR stimulation promoted osteoblast differentiation in bone mesenchymal stem cells via CRY1, with bone regeneration in rat skull defect models significantly accelerated — directly explaining why pre-bed red light synergizes with the nocturnal bone repair window. → Nature IJOS 2022

Step 2 — LMHFV — ~5-20 min — Main Part

Device: Q2 Mini, foam ball head

Here are the optimal hz ranges for goals:

1. 42.2 Hz significantly promoted osteoblast proliferation and increased alkaline phosphatase activity and ALP gene expression.
2. At 90 Hz the COX-2 mRNA level was elevated 3.4-fold. (not possible with this massage gun)
3. RANKL suppression max at ~60hz(possible depending on massage gun)
4. Around 30 Hz significantly prevents bone loss with minimal mechanical strain.
5. LMHF mechanical loading at 0.1–0.4g acceleration at 30 Hz stimulated an osteogenic response requiring BMP expression, inducing alkaline phosphatase activity, enhancing mineralization, and increasing osteogenic gene expression.

I’d recommend playing around between 40hz and 30hz which on this massage gun are:

1. Speed 1: ~30 Hz
2. Speed 2: ~35 Hz
3. ⭐️ Speed 3: ~40 Hz
4. Speed 4: ~45 Hz
5. Speed 5: ~50 Hz

Next up we need an amplitude of sub .3g

This may seem hard to hit considering the massage gun has a stroke of 7mm, but this is where the cloth comes in. For the cloth I used it’s around 5mm thick when folded twice(4 layers), to get to the amplitude needed you can experiment between this and 3 folds which would be 8 layers, 10mm thick.

Base Process: Fold microfiber cloth 2-3 times depending on thickness and place between foam ball and skin. Press lightly, 10-30% pressing power, deep buzzing only, no impact feeling at all. If you feel percussive impact the cloth needs another fold or press lighter. Also to maximize effects KEEP THE MASSAGE GUN IN THE SAME PLACE no sliding it around, this will maximize the effect on the fluid which is what stimulates osteocytes.

Step 3 — RED LIGHT FINISH — ~8 minutes — Optional but recommended

Device: SAVILER red light 

How: Same as Step 1. Hold 8 inches from face, special glasses, both wavelengths, maximum brightness. ~6-10 minutes.

Why this is the most important red light phase: Osteoblasts have just been recruited and are in active state. Giving them red light now will amplify ATP production and will sustain Runx2 as well as do a bunch of other shit u can look into if u want. Basically, this will accelerate the healing process and amplify the effects of the previous steps

Studies(summarized by AI)

1. Red (635nm) and NIR (808nm) photobiomodulation on human osteoblasts and mesenchymal stromal cells — red light at 635nm activated Akt signaling in human osteoblasts, while NIR at 808nm modified Runx2 expression and mineralization pattern, directly validating the wavelengths the SAVILER emits acting on human osteoblasts. → NCBI PMC — Human Osteoblast Study
2. Red (660nm) and near-infrared (810nm) photobiomodulation stimulates proliferation in human adipose-derived stem cells — Scientific Reports 2017, Nature Publishing Group. Red and NIR wavelengths had positive effects on both proliferation and osteogenic differentiation including measurable RUNX2, osterix, and osteocalcin expression. → Scientific Reports 2017
3. Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1 — International Journal of Oral Science, Nature 2022. NIR stimulation promoted osteoblast differentiation in bone mesenchymal stem cells via CRY1, with bone regeneration in rat skull defect models significantly accelerated — directly explaining why pre-bed red light synergizes with the nocturnal bone repair window. → Nature IJOS 2022

WEEKLY STRUCTURE

Sunday allows the remodeling cycle to advance uninterrupted.

How to perform the protocol

If you just skipped down here read the part above this to understand the base of the protocol.

In the study referenced, they applied LMHFV directly to the back molars, however obviously we can't shove a massage gun into our mouth

So instead, we apply LMHFV to the back molars externally

While this may seem like a disadvantage the skin in the middle actually further dampens the amplitude on top of the cloth meaning you can press harder with less amplitude which is good.

Here is an example protocol using these concepts

Step 1 - Red Light ~5 min

Step 2 - LMHFV

Use the base LMHFV protocol from above.

An example of utilizing it would be:

Right Zygo - ~3 min

Left Zygo - ~3 min

Chin - ~3 min

Left Back Molar - ~2-3 min

Right Back Molar ~2-3 min

For the molars, you can play around with the angle but the general idea is you do it where your back molars are where you can feel them through the skin right above the mandible border.

ALSO

this is more theoretical but considering the bottom molars were able to conduct the LMHFV into the mandible, hitting the top back molars may be able to send vibrations upwards hitting the maxilla potentially affecting zygos, brow ridge, and maybe infras but it may be more risky since it could cause the vibrations to travel into the eyes which can lead to vision issues.

also make sure to hold the massage gun still for max effects, the vibration will travel through the bone if done right

 How to enhance the protocol even more

 Pharmacuticals

1. HGH
2. Androgens(testosterone etc)
3. FGFR3 Inhibitors(theoretical)
4. GH releasing peptides - preferably ipamorelin or GHRP2 since they are the best for pulsatile GH which means more skeletal IGF1
5. Tadalafil/Cialis - low dose

Supplements

1. D3+K2 - if deficient
2. Zinc Picolinate
3. Creatine(theoretical)
4. Lactoferrin - high dose 1000mg+
5. Forskolin - 50mg(has been shown to increase aromitization so be careful)
6. Magnesium Glycinate - Sleep
7. Ashwaganda KSM 66 - sleep and cortisol
8. Vitamin C

Habits

1. Proper tongue posture
2. Proper Posture
3. Hard chewing

Risks

if u feel vibrations in ur eye and vision goes blurry stop or go lighter, it can cause blindness, strain, vision loss etc

Have fun with your new bone

--v4d6--

If you plan on doing this protocol pls take before and afters as well as measurements

(you can measure for free, see what to work on, and compare here https://analysis.v4d6.dev)

Lmk any feedback you guys have and the results u guys get. Ill also be doing this on myself ofc.