heavily inspired by a post i saw on dnp and the growing popularity in reta and wanted to compare them

to lose weight the body must have a greater energy expenditure than intake

your body expends calories via basal metabolic rate, fat oxidation, thermogenesis etc

retatrutide aka reta

reta is a triple antagonist affecting your glp-1,gip and glucagon receptors

glp-1 receptors are found in your hypothalamus and your gastrointestinal tract which means that when reta activates them your body sends signals telling your brain that you are full, while also slowing gastric empyting keeping the food in your stomach in your stomach for longer.

GIP when combined with GLP-1 activation produce insulin more efficiently meaning less insulin is needed. GIP is on your fat cells so increased activation along with GLP-1 improves fat metabolism resulting in fat loss

glucagon raises blood sugar, telling the liver to burn more energy stores which are fat, essentially increasing expenditure via thermogenisis. glucagon also promotes fat oxidation, this means your body use its fat cells as fuel more regularly. this only works due to glp-1 and gip activation as more efficient insulin improves glucose control

2,4-dinitrophenol aka dnp

dnp will kill you if you fuck up

do your research or die

your body converts food energy into atp and heat energy with majority going into atp, when you include dnp much more of your energy turns into heat energy meaning you will lose weight as it uncouples oxidative phosphorylation making your cells less efficient in its production, this means that your body will use its fat to create more atp increasing base metabolic rate and fat oxidation. this allows you to burn more calories making you lose weight very rapidly.

if you take too much dnp, this effect will increase in its power and your cells will heat up leading to heatstroke like symptoms as your cells will keep burning causing your internal temp to increase which can lead to organ failure and probably death

people on dnp have claimed 1 to 1.5kg weight loss weekly on dnp whereas phase 3 reta was 32kg over 80 weeks (0.4kg weekly average)

this shows that dnp is a more efficient weight loss drug than reta however has much more serious side effects

i dont recommend dnp at all

js hop on reta, dnp is better but so dangerous its not used in any kind of manufacturing except for explosives